Molecular mimicry and immune‐mediated diseases
نویسندگان
چکیده
منابع مشابه
Molecular mimicry and immune-mediated diseases.
Molecular mimicry has been proposed as a pathogenetic mechanism for autoimmune disease, as well as a probe useful in uncovering its etiologic agents. The hypothesis is based in part on the abundant epidemiological, clinical, and experimental evidence of an association of infectious agents with autoimmune disease and observed cross-reactivity of immune reagents with host 'self' antigens and micr...
متن کامل[Molecular mimicry in the etiology of autoimmune diseases].
There are currently more than 80 different autoimmune diseases, affecting approximately 100 million people worldwide. The etiology of most autoimmune diseases is unknown. The highest incidence of these diseases is in the developed countries and they are more common in women than in men. Among the most often listed factors responsible for the onset of autoimmunity are genetic predisposition and...
متن کاملMolecular mimicry in human diseases--phenomena or epiphenomena?
Molecular mimicry is one mechanism by which infectious agents (or other exogenous substances) trigger an immune response against the host antigens. When a susceptible host acquires an infection with an organism that has antigens immunologically similar to the host antigens but differ sufficiently, to induce, an immune response when presented to T cells, results in loss of tolerance to host anti...
متن کاملMolecular mimicry
EditoriAL EditoriAL Over the course of evolution, microorganisms have developed innovative survival strategies to thrive in their hosts. 1 The human body is home to many species of bacteria, viruses, fungi, and other invertebrate parasites. Some of these organisms that live and thrive in humans are com-mensals and are harmless. They may be also beneficial to the host as they provide certain nut...
متن کاملHIV and Molecular Mimicry
For more than three decades, molecular mimicry has been considered a contributing factor in viral pathogenesis. The phenomenon comes about when viral antigens share epitopes with host cell proteins. Because tolerance is thought never to be complete, the mimicking microbe can induce anti-self antibodies, a state of autoimmunity, with resulting immunopathogenesis. This mode of attack seems preemi...
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ژورنال
عنوان ژورنال: The FASEB Journal
سال: 1998
ISSN: 0892-6638,1530-6860
DOI: 10.1096/fasebj.12.13.1255